On November 29, 2024, according to the Resource Library, the University of Twinter’s research team in the Netherlands recently made a major breakthrough in the field of Bio-sur-Biais. Vascularization of fabrics. The results of the search for this technology were published in the journal Advanced Health Materials entitled “Bio-sur Programmable bioinks based on the Aptimers to regulate the generation of 4D microvascular morphology”. Bioenk is capable of accurately controlling the growth and tissue of blood vessels in 3D printed tissues which seem to “imitate” the complex network of blood vessels of the body.
3D printed bodies are considered a revolutionary advance in the field of medicine and can provide new solutions to organ failure and tissue damage. However, if the printed fabric can obtain enough nutrients and oxygen remains a huge challenge. Without the support of blood vessels, these tissues cannot effectively absorb nutrients or eliminate waste, thus affecting their function and survival. Therefore, if blood vessels can be successfully built in 3D printing have become the key to whether this technology can be applied.
Although previous researchers can organize the arrangement of blood vessels during biopriting, these blood vessels often undergo unpredictable changes after being cultivated in the laboratory or transplanted into the body, affecting the efficiency of the fabric. This programmable bioinque developed by the team of Twente University can dynamically control the process of growth and reshaping of blood vessels.
What is unique in this biose is that it is modified by an aptamra, a small DNA fragment, which can release biochemical signals if necessary. This method simulates natural physiological processes in the human body and in tissue microenvironment, growth signals will only be released if necessary. Therefore, this ink can accurately regulate the formation of blood vessels and guide its development according to tissue needs. “We have already developed an Aptimère technology, which can promote the growth of new blood vessels, but the innovation of this technology is that it can not only control blood vessels in three -dimensional spaces,” said Laboratory Researchers Vascularization of Twente University. Also be dynamically regulated over time, which we call “4D control”.
Going further, the research team combined this technology with 3D printing to develop this programmable biose. It can precisely release biochemical signals in a controlled environment such as the human body and guide the growth of blood vessels. This technology brings us closer to the creation of engineering fabrics which is functionally realistic and as a real organ.
